ABSTRACT
SARS-CoV-2, the cause of COVID-19, is the newest member of the Coronaviridae family of viruses and is the third coronavirus crossing animal species barriers to infect human populations. Systemic ozone therapy can be potentially useful in SARS-CoV-2. The rationale and mechanism of action has already been proven clinically with other viral infections similar to SARS-CoV-2. Here we report the history of ozone therapy, its activity against infectious agents, and techniques which are likely to be the most efficient in culling the massive virion waves that viremic episodes spawn. Ozone is reported to activate the immune system in infectious diseases to improve the utilization of oxygen and stimulate release of growth factors and other mediators that may re-activate the immune system and reduce ischemia in vascular disease, now known to be a significant contributor to adverse Covid-19 outcomes. Ozone therapy may be an important adjuvant to more conventional therapies such as vaccines in severe infectious disease and pandemics including that caused by SARS- CoV-2.